In 65, Gaius Calpurnius Piso, a Roman statesman, organized a conspiracy against Nero with the help of Subrius Flavus, a praetorian tribune, and Sulpicius Asper, a centurion. According to Tacitus, many conspirators wished to "rescue the State" from the emperor and restore the Republic. The freedman Milichus discovered the conspiracy and reported it to Nero's secretary, Epaphroditus. As a result, the conspiracy failed and its members were executed including Nero's former friend Lucanus, the poet. Nero's previous advisor, Seneca was ordered to commit suicide after admitting he discussed the plot with the conspirators.

